Deletion of Setd2 Aggravates Gastric Adenoma Induced by c-Myc Overexpression Involving PI3K/AKT Signaling Pathway
Globally, gastric cancer (GC) is an urgent health concern, necessitating an understanding of its genetic and epigenetic regulation.The Nasal Cleanser tumor suppressor Setd2, H3K36me3 methyltransferase, has been associated with malignancies.The underlying signaling mechanisms and the function of Setd2 in GC aggravation are yet unclear.To figure out